Diabetes and Neurodegeneration

by Debasis Bagchi PhD (ed.), Samudra Prosad Banik PhD (ed.), Rameshwar Nath Chaurasia (ed.) Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challenges. This book begins with a simple guide to understanding high blood sugar, tracing the historical milestones of hyperglycemia, and unveiling the primary factors that contribute to diabetes development, from genetic predisposition to lifestyle hazards. The second section aims to bridge the gap between diabetes and dementia, presenting early clinical evidence, case studies, and susceptibility assessments that underscore the strong link between hyperglycemia and neurodegeneration. Biomarkers and pathways connecting these conditions are explored, including the role of Advanced Glycated End (AGE) products and their implications in protein misfolding and aggregation. The narrative extends to therapeutic strategies, evaluating the efficacy of antidiabetic drugs, targeting insulin resistance, and introducing novel interventions to arrest amyloid-associated pathogenesis. This comprehensive guide provides both clinicians and researchers with a thorough understanding of the intricate link between diabetes and neurodegeneration. - Identifies the cognitive impairment symptoms and the direct impact on the nervous system's structure and electrophysiology - Explores disruptions in insulin signaling as key contributors to neurodegeneration in hyperglycemic individuals - Highlights early diagnostic and prognostic indicators of diabetes and cognitive impairment - Discusses signaling pathways including the insulin signaling pathway and the AGE-RAGE axis that connect diabetes and dementia - Evaluates the efficacy of antidiabetic drugs, targets insulin resistance, and critically assesses RAGE-based therapeutic interventions - Presents novel therapeutics to arrest and delink diabetes from the progression of cognitive impairment